ABSTRACT: Metal-organic frameworks (MOFs) is one of the versatile classes of crystalline porous materials owing to their exceptionally high surface areas, tunable pore architecture and flexible metal-ligand chemistry. In recent years, the integration of bioinspired ligands and MOFs’ principal design has gained attention as an effective strategy to enhance their selectivity, efficiency and functionality in catalytic and sensing applications. This review provides a comprehensive overview of recent advances in synthesis, functionalization strategies such as defect engineering, post-synthetic modification and composite formation are highlighted as powerful tools for tailoring active sites and improving stability and performance. Furthermore, recent developments in MOF-based sensing platforms are reviewed, illustrating how bioinspired MOfs function as Nanozymes, optical transducers and electrochemical sensors for the selective detection of biomolecules. This review aims to provide valuable insight for the rational design of next generation MOFs materials for sustainable catalysts and advanced sensing technologies.
Keywords: Metal-organic framework, Catalysis, Sensing, Bioinspired ligands