In Silico Studies of Fenugreek Seeds’ Phytochemicals Anti-Aging Compounds

Abstract: Ageing is the accelerated loss of forms and functions of cellular components. Pathological ageing affects every human. AMP-activated protein kinase (AMPK) and Mammalian target of rapamycin (mTOR) mTOR proteins play major roles in maintaining cellular energy homeostasis by noticing and responding to AMP/ATP level and nutrients for protein synthesis. AMPK and mTOR have been implicated in various spectrum of aging-associated diseases like cancer, diabetes and cardiovascular diseases. Inhibition of mToR protein has been engaged in the treatment of diseases by targeting the P13k/AKT pathway while the activation of AMPK is believed to extend lives. This computational approach compares phytochemicals from T. foenum in activation of AMPK to a standard drug (segluromet) in clinical trial and the inhibitory capacity of T. foenum on MToRC1 complex through the FK506 Binding Protein binary complex which interact with the mToR protein, also compared with SAFIT2 and rapamycin which inhibit mTOR to bring about autophapy or inhibition of protein synthesis and fat accumulation in the body. Our result shows that T foenum phytochemicals could be considered as potential AMPK activators and Inhibitors of mTOR pathway. Hence, we can recommend it for in vivo study.

Keywords: Ageing, AMPK, mTOR Protein, T. foenum, Seglurome.